| Career Pitching | |||||||||||||||||||
| Thru 2024 | |||||||||||||||||||
| Games Finished | |||||||||||||||||||
| Name | GP | GS | CG | ShO | GF | W | L | Sv | IP | ER | H | SO | BB | ERA | OBA* | WHIP | SO/9 | BB/9 | H/9 |
| Rivera, Mariano | 809 | 0 | 0 | 0 | 640 | 87 | 87 | 383 | 1121.1 | 379 | 707 | 1018 | 351 | 3.04 | .174 | 0.94 | 8.17 | 2.82 | 5.67 |
| Hoffman, Trevor | 591 | 0 | 0 | 0 | 403 | 57 | 65 | 158 | 802.1 | 353 | 598 | 727 | 266 | 3.96 | .199 | 1.08 | 8.15 | 2.98 | 6.71 |
| Wagner, Billy | 537 | 0 | 0 | 0 | 303 | 61 | 38 | 111 | 783.2 | 279 | 520 | 764 | 327 | 3.20 | .181 | 1.08 | 8.77 | 3.76 | 5.97 |
| Jansen, Kenley | 413 | 0 | 0 | 0 | 297 | 39 | 42 | 140 | 708.1 | 273 | 514 | 799 | 221 | 3.47 | .195 | 1.04 | 10.15 | 2.81 | 6.53 |
| Nathan, Joe | 500 | 0 | 0 | 0 | 283 | 41 | 55 | 139 | 597.1 | 285 | 453 | 542 | 252 | 4.29 | .202 | 1.18 | 8.17 | 3.80 | 6.83 |
| Papelbon, Jon | 450 | 0 | 0 | 0 | 247 | 46 | 44 | 91 | 603.1 | 216 | 390 | 541 | 248 | 3.22 | .177 | 1.06 | 8.07 | 3.70 | 5.82 |
| Rodriguez, Francisco | 449 | 0 | 0 | 0 | 234 | 39 | 35 | 49 | 704.2 | 268 | 458 | 654 | 300 | 3.42 | .178 | 1.08 | 8.35 | 3.83 | 5.85 |
| O'Day, Darren | 362 | 0 | 0 | 0 | 232 | 21 | 24 | 143 | 461.1 | 180 | 306 | 473 | 176 | 3.51 | .181 | 1.04 | 9.23 | 3.43 | 5.97 |
| Mesa, Jose | 326 | 0 | 0 | 0 | 221 | 37 | 54 | 53 | 504 | 270 | 436 | 377 | 195 | 4.82 | .224 | 1.25 | 6.73 | 3.48 | 7.79 |
| Foulke, Keith | 316 | 0 | 0 | 0 | 216 | 32 | 26 | 93 | 465 | 169 | 293 | 450 | 173 | 3.27 | .174 | 1.00 | 8.71 | 3.35 | 5.67 |
| Eckersley, Dennis | 459 | 77 | 27 | 3 | 215 | 61 | 89 | 83 | 1131.2 | 528 | 540 | 826 | 307 | 4.20 | .137 | 0.75 | 6.57 | 2.44 | 4.29 |
| Wetteland, John | 363 | 0 | 0 | 0 | 212 | 26 | 25 | 67 | 474.1 | 233 | 390 | 466 | 179 | 4.42 | .215 | 1.20 | 8.84 | 3.40 | 7.40 |
| Jones, Doug | 443 | 0 | 0 | 0 | 211 | 45 | 51 | 73 | 678.1 | 250 | 527 | 535 | 192 | 3.32 | .206 | 1.06 | 7.10 | 2.55 | 6.99 |
| Melancon, Mark | 384 | 0 | 0 | 0 | 207 | 29 | 35 | 96 | 498.1 | 181 | 333 | 407 | 161 | 3.27 | .182 | 0.99 | 7.35 | 2.91 | 6.01 |
| Kimbrell, Craig | 360 | 0 | 0 | 0 | 205 | 36 | 35 | 98 | 475 | 192 | 316 | 692 | 196 | 3.64 | .182 | 1.08 | 13.11 | 3.71 | 5.99 |
| Shaw, Jeff | 323 | 0 | 0 | 0 | 199 | 42 | 37 | 71 | 416.1 | 153 | 273 | 328 | 119 | 3.31 | .179 | 0.94 | 7.09 | 2.57 | 5.90 |
| Hendriks, Liam | 264 | 0 | 0 | 0 | 198 | 16 | 17 | 116 | 374.1 | 123 | 248 | 408 | 81 | 2.96 | .181 | 0.88 | 9.81 | 1.95 | 5.96 |
| Quantrill, Paul | 360 | 2 | 0 | 0 | 196 | 45 | 35 | 56 | 513.2 | 182 | 374 | 345 | 161 | 3.19 | .195 | 1.04 | 6.04 | 2.82 | 6.55 |
| Nen, Robb | 352 | 0 | 0 | 0 | 195 | 36 | 31 | 57 | 549.2 | 235 | 426 | 543 | 220 | 3.85 | .205 | 1.18 | 8.89 | 3.60 | 6.98 |
| Percival, Troy | 340 | 0 | 0 | 0 | 189 | 37 | 36 | 61 | 525 | 188 | 344 | 529 | 224 | 3.22 | .179 | 1.08 | 9.07 | 3.84 | 5.90 |
| Jackson, Mike | 361 | 0 | 0 | 0 | 183 | 44 | 34 | 48 | 593.1 | 243 | 478 | 458 | 217 | 3.69 | .212 | 1.17 | 6.95 | 3.29 | 7.25 |
| Franco, John | 521 | 0 | 0 | 0 | 180 | 57 | 62 | 84 | 845.2 | 371 | 619 | 650 | 337 | 3.95 | .196 | 1.13 | 6.92 | 3.59 | 6.59 |
| Uehara, Koji | 347 | 0 | 0 | 0 | 179 | 27 | 32 | 109 | 364.1 | 139 | 263 | 403 | 86 | 3.43 | .194 | 0.96 | 9.96 | 2.12 | 6.50 |
| Beck, Rod | 323 | 0 | 0 | 0 | 175 | 25 | 35 | 50 | 387 | 175 | 307 | 335 | 114 | 4.07 | .209 | 1.09 | 7.79 | 2.65 | 7.14 |
| Smith, Lee | 440 | 0 | 0 | 0 | 173 | 45 | 42 | 56 | 689.2 | 309 | 479 | 559 | 246 | 4.03 | .188 | 1.05 | 7.29 | 3.21 | 6.25 |
| Soria, Joakim | 340 | 0 | 0 | 0 | 173 | 26 | 31 | 57 | 470 | 213 | 358 | 455 | 190 | 4.08 | .202 | 1.17 | 8.71 | 3.64 | 6.86 |
| Ward, Duane | 277 | 0 | 0 | 0 | 173 | 24 | 21 | 55 | 441 | 164 | 353 | 355 | 161 | 3.35 | .211 | 1.17 | 7.24 | 3.29 | 7.20 |
| Howell, Jay | 309 | 9 | 2 | 1 | 172 | 38 | 29 | 110 | 504 | 187 | 281 | 401 | 173 | 3.34 | .157 | 0.90 | 7.16 | 3.09 | 5.02 |
| Iglesias, Raisel | 389 | 0 | 0 | 0 | 172 | 19 | 35 | 101 | 441 | 149 | 269 | 484 | 155 | 3.04 | .169 | 0.96 | 9.88 | 3.16 | 5.49 |
| Street, Huston | 348 | 0 | 0 | 0 | 172 | 32 | 24 | 62 | 504.2 | 223 | 383 | 434 | 180 | 3.98 | .202 | 1.12 | 7.74 | 3.21 | 6.83 |
| Eichhorn, Mark | 318 | 0 | 0 | 0 | 172 | 43 | 30 | 61 | 619.2 | 178 | 402 | 463 | 200 | 2.59 | .178 | 0.97 | 6.72 | 2.90 | 5.84 |
| Veres, Dave | 234 | 0 | 0 | 0 | 169 | 19 | 18 | 53 | 348 | 168 | 300 | 306 | 132 | 4.34 | .223 | 1.24 | 7.91 | 3.41 | 7.76 |
| Hernandez, Roberto | 317 | 0 | 0 | 0 | 167 | 41 | 30 | 30 | 502.1 | 206 | 360 | 402 | 200 | 3.69 | .193 | 1.11 | 7.20 | 3.58 | 6.45 |
| Hawkins, Latroy | 326 | 0 | 0 | 0 | 161 | 38 | 31 | 61 | 503.1 | 192 | 347 | 371 | 159 | 3.43 | .187 | 1.01 | 6.63 | 2.84 | 6.20 |
| Romo, Sergio | 335 | 0 | 0 | 0 | 159 | 30 | 18 | 74 | 449.1 | 161 | 339 | 477 | 120 | 3.22 | .201 | 1.02 | 9.55 | 2.40 | 6.79 |
| Holland, Al | 215 | 0 | 0 | 0 | 156 | 22 | 23 | 26 | 333 | 120 | 51 | 249 | 121 | 3.24 | .049 | 0.52 | 6.73 | 3.27 | 1.38 |
| Gordon, Tom | 325 | 61 | 5 | 1 | 152 | 40 | 50 | 36 | 726 | 344 | 629 | 642 | 323 | 4.26 | .224 | 1.31 | 7.96 | 4.00 | 7.80 |
| Cormier, Rheal | 300 | 24 | 5 | 0 | 152 | 36 | 33 | 25 | 601.2 | 322 | 546 | 411 | 210 | 4.82 | .232 | 1.26 | 6.15 | 3.14 | 8.17 |
| Perkins, Glen | 299 | 9 | 1 | 0 | 152 | 20 | 25 | 54 | 416.2 | 180 | 339 | 314 | 122 | 3.89 | .213 | 1.11 | 6.78 | 2.64 | 7.32 |
| Assenmacher, Paul | 335 | 0 | 0 | 0 | 151 | 31 | 28 | 28 | 571.2 | 258 | 479 | 422 | 187 | 4.06 | .218 | 1.17 | 6.64 | 2.94 | 7.54 |
| McElroy, Chuck | 257 | 0 | 0 | 0 | 150 | 23 | 27 | 49 | 364.1 | 201 | 323 | 286 | 146 | 4.97 | .228 | 1.29 | 7.06 | 3.61 | 7.98 |
| Robertson, David | 241 | 0 | 0 | 0 | 150 | 22 | 27 | 55 | 454.2 | 187 | 345 | 492 | 192 | 3.70 | .202 | 1.18 | 9.74 | 3.80 | 6.83 |