| Career Pitching | |||||||||||||||||||
| Thru 2024 | |||||||||||||||||||
| Saves | |||||||||||||||||||
| Name | GP | GS | CG | ShO | GF | W | L | Sv | IP | ER | H | SO | BB | ERA | OBA* | WHIP | SO/9 | BB/9 | H/9 |
| Rivera, Mariano | 809 | 0 | 0 | 0 | 640 | 87 | 87 | 383 | 1121.1 | 379 | 707 | 1018 | 351 | 3.04 | .174 | 0.94 | 8.17 | 2.82 | 5.67 |
| Hoffman, Trevor | 591 | 0 | 0 | 0 | 403 | 57 | 65 | 158 | 802.1 | 353 | 598 | 727 | 266 | 3.96 | .199 | 1.08 | 8.15 | 2.98 | 6.71 |
| O'Day, Darren | 362 | 0 | 0 | 0 | 232 | 21 | 24 | 143 | 461.1 | 180 | 306 | 473 | 176 | 3.51 | .181 | 1.04 | 9.23 | 3.43 | 5.97 |
| Jansen, Kenley | 413 | 0 | 0 | 0 | 297 | 39 | 42 | 140 | 708.1 | 273 | 514 | 799 | 221 | 3.47 | .195 | 1.04 | 10.15 | 2.81 | 6.53 |
| Nathan, Joe | 500 | 0 | 0 | 0 | 283 | 41 | 55 | 139 | 597.1 | 285 | 453 | 542 | 252 | 4.29 | .202 | 1.18 | 8.17 | 3.80 | 6.83 |
| Hendriks, Liam | 264 | 0 | 0 | 0 | 198 | 16 | 17 | 116 | 374.1 | 123 | 248 | 408 | 81 | 2.96 | .181 | 0.88 | 9.81 | 1.95 | 5.96 |
| Wagner, Billy | 537 | 0 | 0 | 0 | 303 | 61 | 38 | 111 | 783.2 | 279 | 520 | 764 | 327 | 3.20 | .181 | 1.08 | 8.77 | 3.76 | 5.97 |
| Howell, Jay | 309 | 9 | 2 | 1 | 172 | 38 | 29 | 110 | 504 | 187 | 281 | 401 | 173 | 3.34 | .157 | 0.90 | 7.16 | 3.09 | 5.02 |
| Uehara, Koji | 347 | 0 | 0 | 0 | 179 | 27 | 32 | 109 | 364.1 | 139 | 263 | 403 | 86 | 3.43 | .194 | 0.96 | 9.96 | 2.12 | 6.50 |
| Henke, Tom | 338 | 0 | 0 | 0 | 129 | 29 | 24 | 107 | 549 | 172 | 377 | 530 | 190 | 2.82 | .186 | 1.03 | 8.69 | 3.11 | 6.18 |
| Iglesias, Raisel | 389 | 0 | 0 | 0 | 172 | 19 | 35 | 101 | 441 | 149 | 269 | 484 | 155 | 3.04 | .169 | 0.96 | 9.88 | 3.16 | 5.49 |
| Kimbrell, Craig | 360 | 0 | 0 | 0 | 205 | 36 | 35 | 98 | 475 | 192 | 316 | 692 | 196 | 3.64 | .182 | 1.08 | 13.11 | 3.71 | 5.99 |
| Melancon, Mark | 384 | 0 | 0 | 0 | 207 | 29 | 35 | 96 | 498.1 | 181 | 333 | 407 | 161 | 3.27 | .182 | 0.99 | 7.35 | 2.91 | 6.01 |
| Foulke, Keith | 316 | 0 | 0 | 0 | 216 | 32 | 26 | 93 | 465 | 169 | 293 | 450 | 173 | 3.27 | .174 | 1.00 | 8.71 | 3.35 | 5.67 |
| Papelbon, Jon | 450 | 0 | 0 | 0 | 247 | 46 | 44 | 91 | 603.1 | 216 | 390 | 541 | 248 | 3.22 | .177 | 1.06 | 8.07 | 3.70 | 5.82 |
| Holland, Greg | 192 | 0 | 0 | 0 | 142 | 16 | 18 | 91 | 229 | 83 | 127 | 259 | 94 | 3.26 | .156 | 0.97 | 10.18 | 3.69 | 4.99 |
| Franco, John | 521 | 0 | 0 | 0 | 180 | 57 | 62 | 84 | 845.2 | 371 | 619 | 650 | 337 | 3.95 | .196 | 1.13 | 6.92 | 3.59 | 6.59 |
| Eckersley, Dennis | 459 | 77 | 27 | 3 | 215 | 61 | 89 | 83 | 1131.2 | 528 | 540 | 826 | 307 | 4.20 | .137 | 0.75 | 6.57 | 2.44 | 4.29 |
| Bleier, Richard | 192 | 1 | 0 | 0 | 118 | 8 | 20 | 81 | 222 | 88 | 156 | 140 | 56 | 3.57 | .190 | 0.95 | 5.68 | 2.27 | 6.32 |
| Jenks, Bobby | 190 | 0 | 0 | 0 | 139 | 11 | 16 | 78 | 233 | 71 | 153 | 199 | 88 | 2.74 | .180 | 1.03 | 7.69 | 3.40 | 5.91 |
| Otero, Dan | 159 | 0 | 0 | 0 | 122 | 16 | 23 | 75 | 233.1 | 63 | 147 | 158 | 47 | 2.43 | .174 | 0.83 | 6.09 | 1.81 | 5.67 |
| Osuna, Roberto | 268 | 0 | 0 | 0 | 111 | 25 | 11 | 75 | 302 | 103 | 211 | 292 | 75 | 3.07 | .189 | 0.95 | 8.70 | 2.24 | 6.29 |
| Romo, Sergio | 335 | 0 | 0 | 0 | 159 | 30 | 18 | 74 | 449.1 | 161 | 339 | 477 | 120 | 3.22 | .201 | 1.02 | 9.55 | 2.40 | 6.79 |
| Jones, Doug | 443 | 0 | 0 | 0 | 211 | 45 | 51 | 73 | 678.1 | 250 | 527 | 535 | 192 | 3.32 | .206 | 1.06 | 7.10 | 2.55 | 6.99 |
| Diaz, Edwin | 169 | 0 | 0 | 0 | 131 | 10 | 14 | 73 | 266 | 97 | 174 | 324 | 89 | 3.28 | .179 | 0.99 | 10.96 | 3.01 | 5.89 |
| Shaw, Jeff | 323 | 0 | 0 | 0 | 199 | 42 | 37 | 71 | 416.1 | 153 | 273 | 328 | 119 | 3.31 | .179 | 0.94 | 7.09 | 2.57 | 5.90 |
| McGee, Jake | 210 | 0 | 0 | 0 | 112 | 11 | 14 | 71 | 254.2 | 87 | 168 | 296 | 93 | 3.07 | .180 | 1.02 | 10.46 | 3.29 | 5.94 |
| Bailey, Andrew | 136 | 0 | 0 | 0 | 99 | 12 | 6 | 70 | 157.1 | 45 | 96 | 172 | 45 | 2.57 | .169 | 0.90 | 9.84 | 2.57 | 5.49 |