| Career World Series | |
| Appearances | |
| Thru 2023 | |
| Name | Appearances |
| Maddux, Greg | 5 |
| Schilling, Curt | 5 |
| Scherzer, Max | 5 |
| Greinke, Zack | 5 |
| Lefferts, Craig | 4 |
| Martinez, Dennis | 4 |
| Martinez, Pedro J. | 4 |
| Oliver, Darren | 4 |
| Rivera, Mariano | 4 |
| Tewksbury, Bob | 4 |
| Verlander, Justin | 4 |
| Bumgarner, Madison | 3 |
| Clemens, Roger | 3 |
| Colon, Bartolo | 3 |
| Cueto, Johnny | 3 |
| de Grom, Jacob | 3 |
| Downs, Scott | 4 |
| Gooden, Dwight | 3 |
| Halladay, Roy | 3 |
| Hoffman, Trevor | 3 |
| Howe, Steve | 3 |
| Hudson, Tim | 3 |
| Kuroda, Hiroki | 3 |
| Montgomery, Jeff | 3 |
| Morris, Matt | 3 |
| Mussina, Mike | 3 |
| Pall, Donn | 3 |
| Pettitte, Andy | 3 |
| Quantrill, Paul | 3 |
| Rogers, Steve | 3 |
| Sabathia, C.C. | 3 |
| Shaw, Jeff | 3 |
| Tekulve, Kent | 3 |
| Timlin, Mike | 3 |
| Tudor, John | 3 |
| Watson, Tony | 3 |